Sonic Hedgehog anticorps

N° du produit ABIN6147930

L’anticorps Lapin Monoclonal anti-Sonic Hedgehog a été validé pour WB et IF. Il convient pour détecter Sonic Hedgehog dans des échantillons de Humain.

Aperçu rapide pour Sonic Hedgehog anticorps (ABIN6147930)

Antigène: Sonic Hedgehog (SHH)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Sonic Hedgehog est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-Sonic Hedgehog anticorps

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human Sonic Hedgehog (Shh) (Shh)

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000, IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Sonic Hedgehog

Antigène: Sonic Hedgehog (SHH)

Autre désignation: SHH

Sujet: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.,HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS,Angiogenesis,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Embryonic Stem Cells,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,Hedgehog Signaling Pathway,Neural Stem Cells,Stem Cells,Tumor suppressors,SHH

Poids moléculaire: 51 kDa

ID gène: 6469

UniProt: Q15465

Pathways: Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development